Article
Epithelial sodium channel allele T594M is not associated with blood pressure or blood pressure response to amiloride.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2006
Hollier John M, Martin Dan F, Bell Darin M, Li Jia-Ling, Chirachanchai Mike G, Menon Dileep V, Leonard David, Wu Xiaodong, Cooper Richard S, McKenzie Colin, Victor Ronald G, Auchus Richard J
Abstract excerpt
The T594M allele of the epithelial sodium channel beta-subunit has been proposed as a gain-of-function mutation leading to salt-sensitive hypertension in blacks that is particularly responsive to the specific sodium channel antagonist amiloride. However, the positive associations derive from small convenience samples, and the amiloride challenge study lacked a control group. We determined whether the T594M allele...
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