Article
Detection by ligase chain reaction of precore mutant of hepatitis B virus.
Hepatology (Baltimore, Md.) - 1 Jan 1997
Minamitani S, Nishiguchi S, Kuroki T, Otani S, Monna T
Abstract excerpt
The clinical diagnosis of infection with the most common precore mutant of hepatitis B virus (HBV), that with a point mutation from guanine to adenine at nucleotide 83 in the precore region, is important because the disease may progress rapidly despite interferon therapy. A practical method to detect this mutant is needed. With the ligase chain reaction (LCR), target DNA sequences can be amplified and single base...
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