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Article

Detection of the rtA181V/T and rtN236T mutations associated with resistance to adefovir dipivoxil using a ligase detection reaction assay.

Clinica chimica acta; international journal of clinical chemistry - 1 Oct 2009

Wang Yong-Zhong, Xiao Jun-Hua, Ruan Li-Hua, Zhang Hui-Yin, Chen Min, Pu Xiang-Ke, Shen Hong-Yu, Wu Guo-Xiang

Abstract excerpt

BACKGROUND: Adefovir dipivoxil (ADV) is effective for treatment of chronic hepatitis B virus (HBV) infection, but long-time ADV therapy leads to drug resistance because of HBV reverse transcriptase mutations. We developed a sensitive and specific method for detecting the rtA181V/T and rtN236T mutations associated with ADV resistance in chronic hepatitis B patients, based on a ligase detection reaction (LDR)....

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Source

Identifiers

PMID: 19651117
DOI: 10.1016/j.cca.2009.07.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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