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Article

Sensitive detection of HBsAg mutants by a gap ligase chain reaction assay.

Journal of clinical microbiology - 1 Jul 2002

Osiowy Carla

Abstract excerpt

Hepatitis B virus (HBV) surface gene variants have been associated with diagnostic escape and immune escape following vaccination. The most common mutation observed in these variants is a glycine-to-arginine substitution at amino acid 145 (G145R). In order to sensitively detect the presence of this mutant in serum, a new molecular detection system was developed; in this new system, a gap ligase chain reaction...

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Identifiers

PMID: 12089278
DOI: 10.1128/JCM.40.7.2566-2571.2002
PMCID: PMC120587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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