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Article

The ligase chain reaction distinguishes hepatitis B virus S-gene variants.

FEMS microbiology letters - 1 Sept 1995

Karthigesu V D, Mendy M, Fortuin M, Whittle H C, Howard C R, Allison L M

Abstract excerpt

A novel method for the identification of hepatitis B virus (HBV) variants was developed. The ligase chain reaction (LCR) distinguished the sequences of two isolates from the Gambia showing a change at nucleotide 421 within the region coding for the surface protein a antigenic determinant. One sequence was derived from a child previously immunized with HBV vaccine, while the other, reported here for the first...

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Identifiers

PMID: 7557320
DOI: 10.1111/j.1574-6968.1995.tb07766.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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