Article
The ligase chain reaction distinguishes hepatitis B virus S-gene variants.
FEMS microbiology letters - 1 Sept 1995
Karthigesu V D, Mendy M, Fortuin M, Whittle H C, Howard C R, Allison L M
Abstract excerpt
A novel method for the identification of hepatitis B virus (HBV) variants was developed. The ligase chain reaction (LCR) distinguished the sequences of two isolates from the Gambia showing a change at nucleotide 421 within the region coding for the surface protein a antigenic determinant. One sequence was derived from a child previously immunized with HBV vaccine, while the other, reported here for the first...
Topics
- Base Sequence
- Carrier State
- Child
- DNA Ligases
- DNA, Viral
- Evaluation Studies as Topic
- Gambia
- Genes, Viral
- Genetic Techniques
- Genetic Variation
- Hepatitis B
- Hepatitis B Vaccines