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Article

Evaluation of the ligase chain reaction (LCR) for the detection of point mutations.

Mutation research - 1 Oct 1992

Kälin I, Shephard S, Candrian U

Abstract excerpt

The ligase chain reaction (LCR) was evaluated as an amplification method for an in vivo mutation assay. Specifically, the ligase was tested for its ability to selectively amplify a DNA sequence mutated at a single base, in the presence of an excess of wild-type DNA. As a model template a 370-bp DNA fragment of the mouse Ha-ras protooncogene containing an A to T mutation at the second position of codon 61 was...

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Identifiers

PMID: 1381488
DOI: 10.1016/0165-7992(92)90143-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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