Article
Fulminant hepatitis B: induction by hepatitis B virus mutants defective in the precore region and incapable of encoding e antigen.
Gastroenterology - 1 Apr 1991
Kosaka Y, Takase K, Kojima M, Shimizu M, Inoue K, Yoshiba M, Tanaka S, Akahane Y, Okamoto H, Tsuda F
Abstract excerpt
Clones of hepatitis B virus were propagated from 10 cases of fulminant hepatitis B after amplification by polymerase chain reaction and their nucleotide sequences of the precore region were determined. All 113 clones from 9 cases had a point mutation from guanine to adenine at nucleotide 83 in th...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Base Sequence
- Child
- Child, Preschool
- DNA Mutational Analysis
- DNA, Viral
- Female
- Hepatic Encephalopathy
- Hepatitis B
- Hepatitis B Antibodies
- Hepatitis B e Antigens
- Hepatitis B virus
- Humans
- Infant
- Male
- Middle Aged