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Article

Detection of hepatitis B precore mutants by the fluorescent linear polymerase chain reaction sequencing method.

Journal of hepatology - 1 Dec 1994

Rodriguez-Frias F, Buti M, Arranz J A, Cotrina M, Jardi R, Esteban R, Guardia J

Abstract excerpt

To evaluate the presence of precore mutants, serum samples from 25 patients with chronic hepatitis B, HBV-DNA positive (5 HBeAg and 20 anti-HBe positive) were studied. The complete precore-core region of HBV-DNA was directly sequenced after polymerase chain reaction amplification by a fluorescent linear polymerase chain reaction sequencing method. Precore variants were detected in one HBeAg positive and in all 20...

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PMID: 7699256
DOI: 10.1016/s0168-8278(05)80598-7

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