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Article

A critical role of IL-2 for the production and gene transcription of IL-5 in allergen-specific human T cell clones

1 Jan 1996

Abstract excerpt

The role of IL-2 in IL-5 synthesis of human helper T cells was investigated. All of the Der f II (a major allergen of house dust mite)-specific T cell clones established from atopic asthmatic patients produced both IL-2 and IL-4 upon activation (Th0 phenotypes). Recombinant IL-2 induced gene expression and protein synthesis of IL-5 in T cell clones that produced IL-5 upon antigenic stimulation. Human IL-5...

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Share to Allergic Rhinitis and Sensitization
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PMID: 8982773
DOI: 10.1093/intimm/8.12.1889

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