Article

Cutting Edge: Differential Responsiveness of the IL-5 and IL-4 Genes to Transcription Factor GATA-3

1998-10-01

Abstract excerpt

Abstract The cytokines IL-4 and IL-5 are often coordinately produced by Th2 cells as in asthma. However, it is unclear whether similar molecular mechanisms underlie transcription of the two genes. We have previously shown that the transcription factor GATA-3 is expressed in Th2 but not Th1 cells and is crucial for activation of the IL-5 promoter by different stimuli. In a different study, GATA-3 was shown to be su...

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Literature Corpus work: 85063393-57d3-5b17-beb5-ab8cdfec8235
DOI: 10.4049/jimmunol.161.8.3817

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