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Article

Protein kinase A regulates GATA-3-dependent activation of IL-5 gene expression in Th2 cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2003

Klein-Hessling Stefan, Jha Mithilesh Kumar, Santner-Nanan Brigitte, Berberich-Siebelt Friederike, Baumruker Thomas, Schimpl Anneliese, Serfling Edgar

Abstract excerpt

Treatment of Th cells with compounds that elevate cAMP levels augments Th2-type lymphokine expression, in particular the synthesis of IL-5. Using primary murine CD4(+) T lymphocytes, we show in this study that inhibition of protein kinase A (PKA) activity in Th2 effector cells impairs IL-5 synthesis, whereas the expression of PKA catalytic subunit alpha enhances IL-5 synthesis in Th0 cells. In addition, we...

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Identifiers

PMID: 12626547
DOI: 10.4049/jimmunol.170.6.2956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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