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Article

Isolation of interleukin 2-induced immediate-early genes.

1 Apr 1993

Abstract excerpt

Clonal expansion of antigen-reactive T lymphocytes is driven by the lymphokine interleukin 2 (IL-2). To further elucidate the mechanisms of IL-2 action, we have utilized a differential hybridization procedure to clone IL-2-induced immediate-early genes from an IL-2-stimulated human T-cell cDNA library. To increase the frequency of IL-2-induced transcripts represented in the library, the protein synthesis...

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PMID: 7681987
DOI: 10.1073/pnas.90.7.2719

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