Article
Allelic imbalance on chromosome 5q predicts long-term survival in neuroblastoma.
British journal of cancer - 1 Dec 1996
Meltzer S J, O'Doherty S P, Frantz C N, Smolinski K, Yin J, Cantor A B, Liu J, Valentine M, Brodeur G M, Berg P E
Abstract excerpt
Neuroblastoma is the most common extracranial solid tumour of childhood. Amplification of the proto-oncogene, N-myc, confers a poor prognosis in neuroblastoma, while hyperdiploidy is associated with a favourable outcome. Little is known about the contribution of tumour-suppressor genes to the development or progression of neuroblastoma. We examined allelic imbalance at the locus of the tumour-suppressor gene, APC...
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