Article
CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.
World journal of gastroenterology - 21 Nov 2007
Gao Chang-Ming, Takezaki Toshiro, Wu Jian-Zhong, Chen Min-Bin, Liu Yan-Ting, Ding Jian-Hua, Sugimura Haruhiko, Cao Jia, Hamajima Nobuyuki, Tajima Kazuo
Abstract excerpt
AIM: To investigate associations between the Rsa I polymorphism of CYP2E1 and risk of colorectal cancer. METHODS: A case-control study was conducted with 315 colorectal cancer cases (105 colon, 210 rectal) and 439 population-based controls in Jiangsu Province of China. Genomic DNA samples were assayed for restriction fragment length polymorphisms in CYP2E1 by PCR amplification followed by digestion with Rsa I....
Topics
- Adult
- Aged
- Aged, 80 and over
- Alcohol Drinking
- Case-Control Studies
- China
- Colorectal Neoplasms
- Cytochrome P-450 CYP2E1
- Deoxyribonucleases, Type II Site-Specific
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans