Article
CYP2E1 PstI/RsaI polymorphism and interaction with alcohol consumption in hepatocellular carcinoma susceptibility: evidence from 1,661 cases and 2,317 controls.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2012
Liu Chibo, Wang Haibao, Pan Chunqin, Shen Jianmin, Liang Yong
Abstract excerpt
Many studies have suggested that cytochrome P450 2E1 (CYP2E1) gene might be involved in the development of hepatocellular carcinoma (HCC). However, the results have been inconsistent. In this study, the authors performed a meta-analysis to clarify the association between Pst I/Rsa polymorphism in the CYP2E1 gene and HCC risk. PubMed and China National Knowledge Infrastructure were searched for eligible...
Topics
- Alcohol Drinking
- Alleles
- Binding Sites
- Carcinoma, Hepatocellular
- Case-Control Studies
- Cytochrome P-450 CYP2E1
- Deoxyribonucleases, Type II Site-Specific
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Linkage Disequilibrium