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Article

Functional PstI/RsaI polymorphism in CYP2E1 is associated with the development, progression and poor outcome of gastric cancer.

PloS one - 1 Jan 2012

Feng Jin, Pan Xiaolin, Yu Junbo, Chen Zheng, Xu Hao, El-Rifai Wael, Zhang Guoxin, Xu Zekuan

Abstract excerpt

BACKGROUND: Cytochrome P450 2E1 (CYP2E1), an ethanol-inducible enzyme, has been shown to metabolically activate various carcinogens, which is critical for the development and progression of cancers. It has demonstrated that CYP2E1 polymorphisms alter the transcriptional activity of the gene. However, studies on the association between CYP2E1 polymorphisms (PstI/RsaI or DraI) and gastric cancer have reported...

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Identifiers

PMID: 22957075
DOI: 10.1371/journal.pone.0044478
PMCID: PMC3434136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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