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A mutator phenotype in cancer.

Cancer research - 15 Apr 2001

Loeb L A

Abstract excerpt

We have proposed that an early step in tumor progression is the expression of a mutator phenotype resulting from mutations in genes that normally function in the maintenance of genetic stability. There is new and strong experimental evidence that supports the concept of a mutator phenotype in cancer. As technologies for chromosomal visualization and DNA advance, there are increasing data that human cancer cells...

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PMID: 11309271

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