Article
Perturbation of differentiated functions during viral infection in vivo. In vivo relationship of host genes and lymphocytic choriomeningitis virus to growth hormone deficiency.
The American journal of pathology - 1 Oct 1990
Tishon A, Oldstone M B
Abstract excerpt
Retarded growth and disordered glucose metabolism secondary to growth hormone (GH) deficiency are associated with persistent lymphocytic choriomeningitis virus (LCMV) infection of GH-producing cells in the anterior lobe of the pituitary gland. Infected C3H/ST mice, which are H-2k haplotype, become GH deficient, and LCMV replicates in most (more than 90%) of their GH-producing cells. In contrast, BALB/WEHI and...
Topics
- Animals
- Antibodies, Viral
- Blood Glucose
- Body Weight
- Genes, MHC Class I
- Genetic Predisposition to Disease
- Growth Hormone
- Haplotypes
- Lymphocytic Choriomeningitis
- Lymphocytic choriomeningitis virus