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Article

Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody IgG1b12. off.

Journal of virology - 1 Sept 1997

Mo H, Stamatatos L, Ip J E, Barbas C F, Parren P W, Burton D R, Moore J P, Ho D D

Abstract excerpt

IgG1b12, a human monoclonal antibody (MAb) to an epitope overlapping the CD4-binding site on gp120, has broad and potent neutralizing activity against most primary human immunodeficiency virus type 1 (HIV-1) isolates. To assess whether and how escape mutants resistant to IgG1b12 can be generated,...

Topics

Amino Acid Sequence
Antibodies, Monoclonal
Genetic Variation
HIV Antibodies
HIV Envelope Protein gp120
HIV Envelope Protein gp160
HIV-1
Humans
Immunoglobulin G
Kinetics
Molecular Sequence Data
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutralization Tests

Virus Replication

Source

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Identifiers

PMID: 9261412
DOI: 10.1128/JVI.71.9.6869-6874.1997
PMCID: PMC191968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9261412-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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