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Article

Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody IgG1b12. off.

Journal of virology - 1 Sept 1997

Mo H, Stamatatos L, Ip J E, Barbas C F, Parren P W, Burton D R, Moore J P, Ho D D

Abstract excerpt

IgG1b12, a human monoclonal antibody (MAb) to an epitope overlapping the CD4-binding site on gp120, has broad and potent neutralizing activity against most primary human immunodeficiency virus type 1 (HIV-1) isolates. To assess whether and how escape mutants resistant to IgG1b12 can be generated, we cultured primary HIV-1 strain JRCSF in its presence. An escape mutant emerged which was approximately 100-fold more...

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Identifiers

PMID: 9261412
DOI: 10.1128/JVI.71.9.6869-6874.1997
PMCID: PMC191968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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