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Article

Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2005

Frost Simon D W, Wrin Terri, Smith Davey M, Kosakovsky Pond Sergei L, Liu Yang, Paxinos Ellen, Chappey Colombe, Galovich Justin, Beauchaine Jeff, Petropoulos Christos J, Little Susan J, Richman Douglas D

Abstract excerpt

HIV type 1 (HIV-1) can rapidly escape from neutralizing antibody responses. The genetic basis of this escape in vivo is poorly understood. We compared the pattern of evolution of the HIV-1 env gene between individuals with recent HIV infection whose virus exhibited either a low or a high rate of escape from neutralizing antibody responses. We demonstrate that the rate of viral escape at a phenotypic level is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16339909
DOI: 10.1073/pnas.0504658102
PMCID: PMC1310509

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