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Article

The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner.

Journal of virology - 1 Jul 2005

Saunders Cheryl J, McCaffrey Ruth A, Zharkikh Irina, Kraft Zane, Malenbaum Susan E, Burke Brian, Cheng-Mayer Cecilia, Stamatatos Leonidas

Abstract excerpt

It is well documented that removal of the V1V2 region or of the V2 loop alone from the envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV) increases the susceptibility of these viruses to neutralization by antibodies. The specific role of the V1 loop in defining the neutralization susceptibility of HIV is, however, not well documented. Our current studies...

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Identifiers

PMID: 15994801
DOI: 10.1128/JVI.79.14.9069-9080.2005
PMCID: PMC1168758

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner.PMID 15994801Read ↗

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Genetic diversity of the highly variable V1 region interferes with Human Immunodeficiency Virus type 1 envelope functionality.Semantic proximity Read ↗

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Ability of the V3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4.Semantic proximity Read ↗

A variable region 3 (V3) mutation determines a global neutralization phenotype and CD4-independent infectivity of a human immunodeficiency virus type 1 envelope associated with a broadly cross-reactive, primary virus-neutralizing antibody response.Semantic proximity Read ↗

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