Article
Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2000
Shimizu Y, Nakatsuru Y, Ichinose M, Takahashi Y, Kume H, Mimura J, Fujii-Kuriyama Y, Ishikawa T
Abstract excerpt
The contribution of the aryl hydrocarbon receptor (AhR) in induction of a battery of xenobiotic-metabolizing enzymes has been studied extensively. However, no direct proof has been obtained that it plays a role in modulating carcinogenesis. To address the question of whether AhR is required for tumor induction, we have investigated the response of AhR-deficient mice to benzo[a]pyrene (B[a]P), a widely distributed...
Topics
- Animals
- Benzo(a)pyrene
- Carcinogens
- Carcinoma, Squamous Cell
- Female
- Fibrosarcoma
- Gene Expression
- Genotype
- Keratoacanthoma
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Papilloma