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Article

Mast cell disease associated with acute myeloid leukemia: detection of a new c-kit mutation Asp816His.

American journal of hematology - 1 Dec 2000

Pullarkat V A, Pullarkat S T, Calverley D C, Brynes R K

Abstract excerpt

Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations. c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its ligand stem cell factor induces dimerization, receptor phosphorylation, and signal transduction. The most common c-kit...

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Source

Identifiers

PMID: 11074560
DOI: 10.1002/1096-8652(200012)65:4<307::aid-ajh10>3.0.co;2-f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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