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Article

Pharmaco-phosphoproteomic analysis of cancer-associated KIT mutations D816V and V560G.

Proteomics - 1 May 2024

Murray Heather C, Miller Kasey, Dun Matthew D, Verrills Nicole M

Abstract excerpt

The CD117 mast/stem cell growth factor receptor tyrosine kinase (KIT) is critical for haematopoiesis, melanogenesis and stem cell maintenance. KIT is commonly activated by mutation in cancers including acute myeloid leukaemia, melanoma and gastrointestinal stromal tumours (GISTs). The kinase and the juxtamembrane domains of KIT are mutation hotspots; with the kinase domain mutation D816V common in leukaemia and...

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Source

Identifiers

PMID: 38334196
DOI: 10.1002/pmic.202300309

Genes

KIT
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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