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Article

Dominant negative inhibition by fragments of a monomeric enzyme.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 1996

Michaels J E, Schimmel P, Shiba K, Miller W T

Abstract excerpt

Dominant negative inhibition is most commonly seen when a mutant subunit of a multisubunit protein is coexpressed with the wild-type protein so that assembly of a functional oligomer is impaired. By analogy, it should be possible to interfere with the functional assembly of a monomeric enzyme by interfering with the folding pathway. Experiments in vitro by others suggested that fragments of a monomeric enzyme...

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Identifiers

PMID: 8962072
DOI: 10.1073/pnas.93.25.14452
PMCID: PMC26153

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