Mechanistic insights into global suppressors of protein folding defects.

Abstract excerpt

Most amino acid substitutions in a protein either lead to partial loss-of-function or are near neutral. Several studies have shown the existence of second-site mutations that can rescue defects caused by diverse loss-of-function mutations. Such global suppressor mutations are key drivers of protein evolution. However, the mechanisms responsible for such suppression remain poorly understood. To address this, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to COVID-19
• Share to Mutation
• Share to Protein Folding