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Article

The membrane-targeting-sequence motif is required for exhibition of recessive resurrection in Escherichia coli RNase E.

Nucleic acids research - 24 Jan 2025

Basak Papri, Ekka Manjula, Pandiyan Apuratha, Tandon Smriti, Gowrishankar Jayaraman

Abstract excerpt

The essential homotetrameric endoribonuclease RNase E of Escherichia coli participates in global RNA turnover as well as stable RNA maturation. The protomer's N-terminal half (residues 1-529) bears the catalytic, allosteric, and tetramerization domains, including the active site residues D303 and D346. The C-terminal half (CTH, residues 530-1061) is dispensable for viability. We have previously described a...

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Identifiers

PMID: 39898549
DOI: 10.1093/nar/gkaf055
PMCID: PMC11788932

Genes

CTH

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