Article
Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2012
Bershtein Shimon, Mu Wanmeng, Wu Wanmeng, Shakhnovich Eugene I
Abstract excerpt
Mutations create the genetic diversity on which selective pressures can act, yet also create structural instability in proteins. How, then, is it possible for organisms to ameliorate mutation-induced perturbations of protein stability while maintaining biological fitness and gaining a selective advantage? Here we used site-specific chromosomal mutagenesis to introduce a selected set of mostly destabilizing...
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