Article
Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders.
Journal of the National Cancer Institute - 18 Dec 1996
Hirvonen A, Saarikoski S T, Linnainmaa K, Koskinen K, Husgafvel-Pursiainen K, Mattson K, Vainio H
Abstract excerpt
BACKGROUND: Humans vary in their ability to metabolize endogenous and exogenous compounds. Glutathione S-transferases (GSTs) and N-acetyltransferases (NATs) are enzymes involved in the detoxification of hazardous agents. The GSTM1 and GSTT1 genes exhibit null (i.e., deletion) polymorphisms; in sp...
Topics
- Acetylation
- Adult
- Arylamine N-Acetyltransferase
- Asbestos
- Cohort Studies
- DNA Probes
- Disease Susceptibility
- Finland
- Gene Deletion
- Genotype
- Glutathione Transferase
- Homozygote
- Humans
- Lung Diseases
- Lung Neoplasms
- Middle Aged
- Occupational Diseases
- Occupational Exposure