Article
Rapid and intermediate N-acetylators are less susceptible to oxidative damage among 4,4'-methylenebis(2-chloroaniline) (MBOCA)-exposed workers.
International journal of hygiene and environmental health - 1 Jul 2013
Lin I-Shen, Fan Pao-Lou, Chen Hong-I, Loh Ching-Hui, Shih Tung-Sheng, Liou Saou-Hsing
Abstract excerpt
OBJECTIVES: In this study, we explored the association between a marker of oxidative stress, 8-hydroxydeoxyguanosine (8-OHdG), and genetic polymorphism of the carcinogen-metabolizing enzyme N-acetyltransferase 2 (NAT2) among 4,4'-methylenebis(2-chloroaniline) (MBOCA)-exposed workers. METHODS: The study population was recruited from four MBOCA-producing factories, and included 57 MBOCA-exposed workers and 101...
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