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Article

Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer.

Carcinogenesis - 1 Jul 2008

Yuan Jian-Min, Chan Kenneth K, Coetzee Gerhard A, Castelao J Esteban, Watson Mary A, Bell Douglas A, Wang Renwei, Yu Mimi C

Abstract excerpt

Genetically determined factors that alter the metabolism of tobacco carcinogens can influence an individual's susceptibility to bladder cancer. The associations between the genotypes of glutathione S-transferase (GST) M1, GSTP1, GSTT1 and N-acetyltransferase (NAT) 1 and the phenotypes of NAT2 and cytochrome P450 (CYP) 1A2 and bladder cancer risk were examined in a case-control study involving 731 bladder cancer...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18544563
DOI: 10.1093/carcin/bgn136
PMCID: PMC2720058

Genes

NAT2
GSTM1
GSTP1
GSTT1
CYP1A2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer.PMID 18544563Read ↗

Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women.Semantic proximity Read ↗

Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking.Semantic proximity Read ↗

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Genetic polymorphisms of N-acetyltransferase 1 and 2 and risk of cigarette smoking-related bladder cancer.Semantic proximity Read ↗

NAT1 genotypic and phenotypic contribution to urinary bladder cancer risk: a systematic review and meta-analysis.Semantic proximity Read ↗

NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.Semantic proximity Read ↗

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The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction.Semantic proximity Read ↗

Modifying Effect of Smoking on GSTM1 and NAT2 in Relation to the Risk of Bladder Cancer in Mongolian Population: A Case-Control Study.Semantic proximity Read ↗

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