Article
Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype.
Gene - 11 Jul 2001
Ohmiya N, Matsumoto S, Yamamoto H, Baranovskaya S, Malkhosyan S R, Perucho M
Abstract excerpt
Hereditary and sporadic gastrointestinal cancer of the microsatellite mutator phenotype (MMP) is characterized by a remarkable genomic instability at simple repeated sequences. The genomic instability is often caused by germline and somatic mutations in DNA mismatch repair (MMR) genes hMSH2 and hMLH1. The MMP can be also caused by epigenetic inactivation of hMLH1. The MMP generates many somatic frameshift...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.