Article
Analysis of mutant forms of the c-src gene product containing a phenylalanine substitution for tyrosine 416.
Oncogene research - 1 Jan 1990
Ferracini R, Brugge J
Abstract excerpt
Several lines of evidence suggest that phosphorylation of tyrosine residue 416 (Tyr416) has a positive regulatory influence on the functional activity of the protein tyrosine kinase pp60c-src. To further examine the functional importance of phosphorylation at Tyr416, we have eliminated this phosphoacceptor site in four functionally unique mutant forms of the c-src gene product that are phosphorylated on Tyr416 in...
Topics
- Animals
- Annexins
- Calcium-Binding Proteins
- Cell Transformation, Neoplastic
- Chick Embryo
- Fibroblasts
- Gene Expression
- Genetic Variation
- Immunoblotting
- Mutation
- Phenylalanine