Article
Allelic polymorphism of human FcγRIIA-H/R131 receptor in American tegumentary leishmaniasis.
International journal of immunogenetics - 1 Jun 2011
Oliveira C R, Pereira L I A, Pereira A-J C S, Ferreira A A, Crespo A M C, Silveira L A
Abstract excerpt
FcγRIIA binding to IgG subclasses with different levels of affinity is influenced by the polymorphism in the gene that encodes this receptor. The substitution of arginine (R) for histidine (H) in the 131 position defines three allelic patterns, H/H, R/R, and H/R, resulting in FcγRIIA-H/H131 affinity for IgG2 and higher affinity for IgG3 subclasses. Studies have shown the importance of genetic host factors in...
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