Article
The glutathione S-transferase M1 (GSTM1) null genotype and benzidine-associated bladder cancer, urine mutagenicity, and exfoliated urothelial cell DNA adducts.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 1996
Rothman N, Hayes R B, Zenser T V, DeMarini D M, Bi W, Hirvonen A, Talaska G, Bhatnagar V K, Caporaso N E, Brooks L R, Lakshmi V M, Feng P, Kashyap S K, You X, Eischen B T, Kashyap R, Shelton M L, Hsu F F, Jaeger M, Parikh D J, Davis B B, Yin S, Bell D A
Abstract excerpt
Multiple studies in the general population have suggested that subjects with the glutathione S-transferase M1 (GSTM1)-null genotype, who lack functional GSTM1, are at higher risk for bladder cancer. To evaluate the impact of the GSTM1-null genotype on bladder cancer caused by occupational exposure to benzidine and to determine its influence on benzidine metabolism, we carried out three complementary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.