Article
The impact of interindividual variation in NAT2 activity on benzidine urinary metabolites and urothelial DNA adducts in exposed workers.
Proceedings of the National Academy of Sciences of the United States of America - 14 May 1996
Rothman N, Bhatnagar V K, Hayes R B, Zenser T V, Kashyap S K, Butler M A, Bell D A, Lakshmi V, Jaeger M, Kashyap R, Hirvonen A, Schulte P A, Dosemeci M, Hsu F, Parikh D J, Davis B B, Talaska G
Abstract excerpt
Several epidemiologic studies indicate that NAT2-related slow N-acetylation increases bladder cancer risk among workers exposed to aromatic amines, presumably because N-acetylation is important for the detoxification of these compounds. Previously, we showed that NAT2 polymorphisms did not influence bladder cancer risk among Chinese workers exposed exclusively to benzidine (BZ), suggesting that NAT2 N-acetylation...
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