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Article

Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.

The Journal of clinical investigation - 1 Dec 1996

Lembo G, Rockman H A, Hunter J J, Steinmetz H, Koch W J, Ma L, Prinz M P, Ross J, Chien K R, Powell-Braxton L

Abstract excerpt

To circumvent the embryonic lethality of a complete deficiency in insulin-like growth factor 1 (IGF-1), we generated mice homozygous for a site-specific insertional event that created a mutant IGF-1 allele (igf1m). These mice have IGF-1 levels 30% of wild type yet survive to adulthood, thereby al...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 8958230
DOI: 10.1172/JCI119086
PMCID: PMC507725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8958230-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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