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Article

Status and expression of the p16INK4 gene in human thyroid tumors and thyroid-tumor cell lines.

International journal of cancer - 3 Jul 1996

Calabrò V, Strazzullo M, La Mantia G, Fedele M, Paulin C, Fusco A, Lania L

Abstract excerpt

The p16INK4 tumor-suppressor gene (also known as CDKN2, CDK41 and MTS1) encodes a negative regulator of the cell cycle. This gene, located in 9p21, is mutated or homozygously deleted in a high percentage of tumor cell lines and specific types of primary tumors. We have examined the status of the p16INK4 gene in 31 thyroid tumors and 7 thyroid cell lines. No DNA abnormalities were found in primary tumors....

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Source

Identifiers

PMID: 8690521
DOI: 10.1002/(SICI)1097-0215(19960703)67:1<29::AID-IJC7>3.0.CO;2-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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