Article
Allelic imbalance of the mutant and wild-type RET allele in MEN 2A-associated medullary thyroid carcinoma.
Oncogene - 22 Nov 2001
Koch C A, Huang S C, Moley J F, Azumi N, Chrousos G P, Gagel R F, Zhuang Z, Pacak K, Vortmeyer A O
Abstract excerpt
Germline mutations of the RET proto-oncogene are responsible for the familial tumor syndrome called multiple endocrine neoplasia type 2 (MEN 2) that includes medullary thyroid carcinoma (MTC). Although inherited mutations of RET lead to tumor formation in patients with MEN 2, it is not understood why only selected cells develop into tumors. We have recently shown that duplication of the mutated RET allele or loss...
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