Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of quiescent ABL-transduced hemopoietic stem cells.

Oncogene - 5 Dec 1996

Chung S W, Chen H, Wong P M

Abstract excerpt

Chronic myelogenous leukemia (CML) is a hemopoietic stem cell disorder in which an activated ABL oncogene is expressed and has been shown to play an important role in disease pathogenesis. A mouse model has been established in which hemopoietic stem cells (HSCs) transduced with a retrovirus vector carrying an activated ABL oncogene can be analysed. Using this model, we now report that abl-transduced HSCs can be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fluorouracil
Share to Genetic Vectors
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

Share to Phenotype

Share to Transfection

Share to Virus Integration

Source

Identifiers

PMID: 8957081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of quiescent ABL-transduced hemopoietic stem cells.PMID 8957081Read ↗

Why do chronic myelogenous leukemia stem cells survive allogeneic stem cell transplantation or imatinib: does it really matter?Semantic proximity Read ↗

Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice.Semantic proximity Read ↗

Primitive, Quiescent and Difficult to Kill: The Role of Non-Proliferating Stem Cells in Chronic Myeloid LeukemiaSemantic proximity Read ↗

Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cellsSemantic proximity Read ↗

Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML diseaseSemantic proximity Read ↗

Transcriptional Analysis of Quiescent and Proliferating CD34+ Human Hemopoietic Cells from Normal and Chronic Myeloid Leukemia SourcesSemantic proximity Read ↗

BCR-ABL-transformed GMP as myeloid leukemic stem cellsSemantic proximity Read ↗

Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3.Semantic proximity Read ↗

Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment.Semantic proximity Read ↗

Quiescent murine cells lack global genomic repair but are proficient in transcription-coupled repair.Semantic proximity Read ↗

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cellsSemantic proximity Read ↗

Blast crisis in a murine model of chronic myelogenous leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.