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Article

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

7 Jan 2010

Abstract excerpt

In a previously developed inducible transgenic mouse model of chronic myeloid leukemia, we now demonstrate that the disease is transplantable using BCR-ABL(+) Lin(-)Sca-1(+)c-kit(+) (LSK) cells. Interestingly, the phenotype is more severe when unfractionated bone marrow cells are transplanted, yet neither progenitor cells (Lin(-)Sca-1(-)c-kit(+)), nor mature granulocytes (CD11b(+)Gr-1(+)), nor potential stem cell...

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PMID: 20053753
DOI: 10.1182/blood-2009-04-215376

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