Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells

20 Nov 2023

Abstract excerpt

Quiescent human hematopoietic stem cells (HSC) are ideal targets for gene therapy applications due to their preserved stemness and repopulation capacities; however, they have not been exploited extensively because of their resistance to genetic manipulation. We report here the development of a lentiviral transduction protocol that overcomes this resistance in long-term repopulating quiescent HSC, allowing their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37990494
DOI: 10.1016/j.ymthe.2023.11.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cellsPMID 37990494Read ↗

Antiviral immunity and nucleic acid sensing in haematopoietic stem cell gene engineeringSemantic proximity Read ↗

Advancements in Hematopoietic Stem Cell Gene Therapy: A Journey of Progress for Viral TransductionSemantic proximity Read ↗

Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedentSemantic proximity Read ↗

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cellsSemantic proximity Read ↗

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem CellsSemantic proximity Read ↗

A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemnessSemantic proximity Read ↗

Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy SettingsSemantic proximity Read ↗

Controlled cycling and quiescence enables homology directed repair in engraftment-enriched adult hematopoietic stem and progenitor cellsSemantic proximity Read ↗

human embryonic stem cells: biology and clinical implicationsSemantic proximity Read ↗

Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene TargetingSemantic proximity Read ↗

Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectorsSemantic proximity Read ↗

Hematopoietic stem cells: self-renewal and expansionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.