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Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease

21 Jan 2024

Abstract excerpt

Whilst it is recognised that targeting self-renewal is an effective way to functionally impair the quiescent leukaemic stem cells (LSC) that persist as residual disease in chronic myeloid leukaemia (CML), developing therapeutic strategies to achieve this have proved challenging. We demonstrate that the regulatory programmes of quiescent LSC in chronic phase CML are similar to that of embryonic stem cells,...

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PMID: 38246924
DOI: 10.1038/s41467-024-44771-9

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