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Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment.

Blood - 15 May 1997

Randall T D, Weissman I L

Abstract excerpt

A significant fraction of hematopoietic stem cells (HSCs) have been shown to be resistant to the effects of cytotoxic agents such as 5-fluorouracil (5-FU), which is thought to eliminate many of the rapidly dividing, more committed progenitors in the bone marrow and to provide a relatively enriched population of the most primitive hematopoietic progenitor cells. Although differences between 5-FU-enriched...

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PMID: 9160664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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