Article
Quiescent murine cells lack global genomic repair but are proficient in transcription-coupled repair.
DNA repair - 2 Jul 2004
Bielas Jason H, Heddle John A
Abstract excerpt
The majority of the cells in the body, including stem cells, exist in a quiescent state, so it is in quiescent cells where most DNA damage occurs. It has been uncertain whether or not this damage is repaired or fixed into mutations during quiescence or if proliferation is required for both. Prior to the development of transgenic mice, it was difficult to distinguish between these two possibilities, as cells had...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.