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Article

Embryonic heart and skin defects in mice lacking plakoglobin.

Developmental biology - 15 Dec 1996

Bierkamp C, Mclaughlin K J, Schwarz H, Huber O, Kemler R

Abstract excerpt

Plakoglobin is the only component common to both the desmosomal plaque and the cadherin-catenin cell adhesion complex in the adherens junction. It is highly homologous to vertebrate beta-catenin and to Drosophila armadillo protein and may-like these proteins-be also involved in signaling pathways. To analyze the role of plakoglobin during mouse development we inactivated the plakoglobin gene by homologous...

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Identifiers

PMID: 8954745
DOI: 10.1006/dbio.1996.0346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Embryonic heart and skin defects in mice lacking plakoglobin.PMID 8954745Read ↗

Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.Semantic proximity Read ↗

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.Semantic proximity Read ↗

In vivo function of desmosomes.Semantic proximity Read ↗

Lack of plakoglobin leads to lethal congenital epidermolysis bullosa: a novel clinico-genetic entitySemantic proximity Read ↗

Cardiac Tissue-Restricted Deletion of Plakoglobin Results in Progressive Cardiomyopathy and Activation of β-Catenin SignalingSemantic proximity Read ↗

The Desmosomal Plaque Proteins of the Plakophilin FamilySemantic proximity Read ↗

Plakoglobin has both structural and signalling roles in zebrafish development.Semantic proximity Read ↗

Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathySemantic proximity Read ↗

Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.Semantic proximity Read ↗

Desmosomal genodermatoses.Semantic proximity Read ↗

Generation of a CRISPR/Cas9-edited Plakoglobin (JUP) knock-out (JMUi001-A-4) iPSC line to model the cardiac phenotype of arrhythmogenic cardiomyopathy.Semantic proximity Read ↗

A Central Role for the Armadillo Protein Plakoglobin in the Autoimmune Disease Pemphigus VulgarisSemantic proximity Read ↗

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