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Article

Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy

31 Aug 2011

Abstract excerpt

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inheritable myocardial disorder associated with fibrofatty replacement of myocardium and ventricular arrhythmia. A subset of ARVC is categorized as Naxos disease, which is characterized by ARVC and a cutaneous disorder. A homozygous loss-of-function mutation of the Plakoglobin (Jup) gene, which encodes a major component of the desmosome and the adherens...

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PMID: 21880664
DOI: 10.1093/hmg/ddr392

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Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathyPMID 21880664Read ↗

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