Article
Plakoglobin has both structural and signalling roles in zebrafish development.
Developmental biology - 1 Mar 2009
Martin Eva D, Moriarty Miriam A, Byrnes Lucy, Grealy Maura
Abstract excerpt
Plakoglobin, or gamma-catenin, is found in both desmosomes and adherens junctions and participates in Wnt signalling. Mutations in the human gene are implicated in the congenital heart disorder, arrhythmogenic right ventricular cardiomyopathy (ARVC), but the signalling effects of plakoglobin loss in ARVC have not been established. Here we report that knockdown of plakoglobin in zebrafish results in decreased...
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