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Article

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.

The Journal of cell biology - 1 Oct 1996

Ruiz P, Brinkmann V, Ledermann B, Behrend M, Grund C, Thalhammer C, Vogel F, Birchmeier C, Günthert U, Franke W W, Birchmeier W

Abstract excerpt

Plakoglobin (gamma-catenin), a member of the armadillo family of proteins, is a constituent of the cytoplasmic plaque of desmosomes as well as of other adhering cell junctions, and is involved in anchorage of cytoskeletal filaments to specific cadherins. We have generated a null mutation of the p...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8858175
DOI: 10.1083/jcb.135.1.215
PMCID: PMC2121015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8858175-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.PMID 8858175Read ↗

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