Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.

doi:10.1242/dev.126.2.371

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Article

Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.

Development (Cambridge, England) - 1 Jan 1999

Bierkamp C, Schwarz H, Huber O, Kemler R

Abstract excerpt

Plakoglobin, a protein belonging to the Armadillo-repeat gene family, is the only component that adherens junctions and desmosomes have in common. Plakoglobin null-mutant mouse embryos die because of severe heart defects and may exhibit an additional skin phenotype, depending on the genetic backg...

Topics

Animals
Cadherins
Cell Adhesion
Cell Differentiation
Cytoskeletal Proteins
Desmogleins
Desmoplakins
Desmosomes
Embryo, Mammalian
Embryonic and Fetal Development
Genotype
Immunohistochemistry
Intestinal Mucosa
Keratinocytes
Mice
Mice, Knockout
Microscopy, Electron
Phenotype

Source

Open in PubMed

Identifiers

PMID: 9847250
DOI: 10.1242/dev.126.2.371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9847250-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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